Fate of absorbed glucose

• Glucose is absorbed from the gut within an hour.
• Absorbed glucose is transported into the tissue and the glucose concentration quickly returns to its basal value.
• The liver then converts glucose to glycogen or fatty acid.
• The uptake and utilization of glucose is stimulated by insulin.

a) In muscle, insulin stimulates glycogen deposition by activation of glycogen synthetase and inhibition of phosphorylase.

b) Conversion of glucose to fatty acids is stimulated through effects on pyruvate dehydrogenase and acetyl CoA carboxylase.