Metabolism of lipid

• Lipids are available in our body in two forms majorly triglyceride and phospholipid.
• Triglyceride compose of 85-90 % of total lipid present in the body and are stored in Adipose tissue.
• Whenever one is fasting, the need of lipids is increased.
• To fulfill this need, the triglycerides stored in Adipose tissue is converted to glycerol and fatty acids.

Triglyceride – stored in à Adipose tissue — fasting converts à Glycerols + fatty acids

i.e. Triglycerides ––triglyceride lipase à Glycerol + Fatty acids

• Glycerol is then transported to liver which upon reaction with glycerol kinase produce glycerol-3-phosphate.

i.e. Glycerol ( in liver ) + ATP— Glycerol kinase -à Glycerol-3-phosphate + ADP

• Glycerol-3-phosphate has two fates. Either it gets again converted to triglycerides and Phospholipids or gets converted to DHAP in presence of enzyme glycerol-3-phosphate dehydrogenase.
• The DHAP then enter into glycolysis for further oxidation or again converted into triglyceride and phospholipid.
• The free fatty acids then enter into blood and bind with albumin to become albumin bound fatty acid which is then transferred into tissue for energy production ( β- oxidation).